Ronaldo then thanked the doctors and nurses "for all their care and support."
"We are all devastated at this loss and we kindly ask for privacy at this very difficult time.
"Our baby boy, you are our angel. We will always love you," he concluded.
Ronaldo and Rodriguez announced their pregnancy to great fanfare in October last year, with the sexes of the twins later revealed to be one girl and one boy.
Ronaldo already has an 11-year-old son, Cristiano Jr, who was born in the US in June 2010, and later had twins Eva and Mateo born on US soil via surrogacy in June 2017.
Shortly after, in November that year, Rodriguez gave birth to their only child together, Alana Martina.
Given the tragic news, Ronaldo could possibly be excused from the Premier League clash against Liverpool on Tuesday.
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